P04.01.B High impact of ITGB1 on Pi3K/AKT expression in medulloblastoma

Abstract Medulloblastoma, an embryonal tumor of the cerebellum, is one most frequent malignant brain tumors. Despite increasing use genetic variation in treatment stratification, high-risk patients characterized by light meningeal spread, TP53 mutations, or MYC amplification still have poor survival. Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) signaling important intracellular pathways, which can be considered as a master regulator for cancer. In tissue samples obtained from medulloblastoma patients, significant upregulation PI3K/AKT was associated with lifting expression level integrin β1(ITGB1). To understand underlying mechanism, we investigated effect ITGB1 on pathway cell lines. Transfection this reduced proliferation and invasion several lines inhibit epithelial-mesenchymal transition. addition, knocking down significantly activation pathway. conclusion, may selectively pathophysiological aberrant serve targeted approach therapy.